Table 1.

Pharmacokinetic Parameters for Belinostat After 30 Minutes of Intravenous Infusion

Study Time	Parameter*	Dose Level (mg/m2)
		600	900	1,200	1,400
Day 1	No. of patients	3	3	6	22
	Cmax, ng/mL	28,052 ± 2,710	31,308 ± 9,443	48,800 ± 16,024	58,234 ± 17,865
	tmax, hours	0.35	0.42	0.42	0.45
	AUC0-5 hours, h · ng/mL	18,929 ± 136	21,796 ± 5,490	36,887 ± 10,540	45,596 ± 13,910
	AUC0-24 hours, h · ng/mL	19,499 ± 370	22,267 ± 5,485	38,988 ± 11,781	47,503 ± 14,044
	t1/2, hours	3.54 ± 0.34	4.07 ± 0.39	4.14 ± 0.42	3.49 ± 0.73
	Cl, L/h	52.6 ± 3.75	70.5 ± 17.9	54.6 ± 15.8	54.1 ± 18.0
	Vz, L	268 ± 26.6	409 ± 76.7	305 ± 186	283 ± 151
Day 5	AUC0-5 hours, h · ng/mL	17,770 ± 1,323	20,485 ± 4,965	32,530 ± 8,054	52,555 ± 16,535
Day 5/day 1†	AUC ratio	0.94	0.94	0.88	1.15

Abbreviations: AUC, area under the serum concentration-time curve; AUC_0-t, AUC from 0 to t hours; C_max, maximum serum concentration; Cl, clearance; t_1/2, terminal half-life; t_max, time to maximum serum concentration; V_z, volume of distribution.

^*Mean ± standard deviation except for t_max.

^†AUC ratio is calculated based on AUC_{0-5 hours} on day 5 divided by AUC_{0-5 hours} on day 1.