Fig. 1.

Effects of simvastatin and/or losartan on lipid accumulation in aorta and aortic sinus in apoE^-/- mice fed a high-fat, high-cholesterol (HFHC) diet. Mice were fed an HFHC diet for 12 weeks of HFHC with or without 40 mg/kg simvastatin and/or 20 mg/kg losartan twice weekly. A control group was fed regular chow for 12 weeks. A: representative en face Oil Red O-stained aorta from each group of apoE^-/- mice is shown. B: representative Oil Red O-stained area in aortic sinus from each group of apoE^-/- mice is shown. C: Oil Red O-positive areas of the aortic sinus were quantitatively analyzed by computer-assisted morphometery. All results are shown as the mean±SD. ^*p<0.05 compared with the HFHC group. S: simvastatin, L: losartan, S+L: simvastatin plus losartan, apoE^-/-: apolipopretein E.