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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Mol Microbiol. 2012 Aug 1;85(6):1194–1203. doi: 10.1111/j.1365-2958.2012.08168.x

Fig. 2.

Fig. 2

Comparison of TlyA sequences. The sequence of TlyA from M. tuberculosis H37Rv (NCBI accession number: CAB10951) is compared with orthologs from M. smegmatis MC2 155 (NCBI number YP_888048.1), S. coelicolor A3 (NC_003888), G. stearothermophilus (AB126617), T. thermophilus HB8 (AP008226) and S. hyodysenteriae (X61684). The total numbers of residues in the enzymes together with the percentages that are identical and functionally-similar to the M. tuberculosis sequence are listed on the right; these conserved regions are shown as black bars within the sequences. Based on their lengths, the sequences fall into the two distinct groups TlyAI and TlyAII. A consensus from these orthologs is shown highlighting the conserved S4-type RNA binding motif (S4), the S-adenosylmethionine (SAM) binding domain and three motifs indicative of 2′-O-methyltransferases (K, D and K) (Aravind and Koonin, 1999, Feder et al., 2003, Maus et al., 2005b).