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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2012 Jul 2;11(9):1999–2009. doi: 10.1158/1535-7163.MCT-12-0017

Figure 6. MRK-003 treatment down-regulates nuclear N1ICD and Hes-1 protein expressions in PDAC xenografts as shown by immunohistochemical staining.

Figure 6

A and B: Representative photomicrographs of N1ICD and Hes-1 from Panc291 and Panc374 xenografts showing down-regulation of nuclear N1ICD and Hes-1 expression in MRK-003 and combination of GEM and MRK-003 treatment compared to vehicle treated and GEM treated tumor samples.