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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Int J Antimicrob Agents. 2012 Jul 20;40(4):354–360. doi: 10.1016/j.ijantimicag.2012.05.023

Figure 3.

Figure 3

Vaginal fluid simulant at pH 4.5, 5.5 or 6.5 has little effect on inhibition of HIV-1 by the compounds (a). Inhibition of HIV-1US657 by compound INP0149 is shown, and similar results were obtained with compounds INP0161, INP0341, and INP0400. Similarly, combined vaginal (pH 4.5) and semen (pH 7.7) simulants at a 1:1 vol/vol ratio (b) have little effect on compound activity. Horizontal dotted line indicates 50% virus inhibition.