Table 2.
Effect of salicylidene acylhydrazides on an early HIV-1 reverse transcription product (R-U5 DNA) and on integrated viral DNA1.
| Compound | R-U5 DNA/HAPB | Integrated HIV DNA/HAPB |
|---|---|---|
| Control (no compound) | 17.3 | 9.8 |
| INP0149 | 17.5 | 9.0 |
| INP0161 | 30.6 | ND |
| INP0341 | 39.2 | 7.7 |
| INP0400 | 27.3 | ND |
All compounds were tested at 25μM. Data are reported as DNA copies of HIV sequence per HAPB copy. HAPB serves as a “housekeeping” gene to adjust for the number of TZMbl cells from which DNA was extracted. ND = not done.