Table 1.
The relationships among rs1649942, miRNAs, mRNAs and cellular sensitivity to platinum agents in the HapMap CEU discovery samples.
| rs1649942 association with platinum IC50P value | miRNA | rs1649942-miR association p value | miRNA P value association with platinum IC50 | gene | P values | |||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||||
| carboplatin | cisplatin | Carboplatin | cisplatin | rs16499 42-gene | Gene-carboplatin | Gene-cisplatin | miRNA-gene | |||
| 1E-5 | 7E-5 | miR-193b* | 3.4E-3 | 7.3E-3 | 1.6E-2 | CRIM1 | 3E-5 | 1.0E-4 | 9.8E-4 | 2.8E-5 |
|
|
||||||||||
| IFIT2 | 1E-4 | 1.8E-2 | 7.6E-3 | 6.3E-5 | ||||||
|
|
||||||||||
| OAS1 | 1E-5 | 3.7E-2 | 4.3E-2 | 5.2E-5 | ||||||
|
|
||||||||||
| CCR6 | 5E-5 | 3.3E-2 | 2.0E-2 | 3.1E-4 | ||||||
|
|
||||||||||
| 3.5E-4 | 1.5E-4 | |||||||||
|
|
||||||||||
| CYP2R1 | 1E-4 | 3.3E-4 | 2.5E-3 | 2.0E-2 | ||||||
|
|
||||||||||
| 1E-4 | 2.2E-5 | 1.9E-3 | 2.7E-3 | |||||||
|
|
||||||||||
| KYNU | 9E-6 | 9.3E-4 | 2.7E-4 | 4.8E-3 | ||||||
|
|
||||||||||
| RAPGEF5 | 2E-6 | 2.0E-2 | 4.6E-2 | 1.0E-2 | ||||||
|
|
||||||||||
| SLC2A5 | 2E-5 | 6.1E-3 | 1.5E-3 | 6.6E-3 | ||||||
|
|
||||||||||
| USP12 | 9E-5 | 5.1E-4 | 4.2E-4 | 1.3E-3 | ||||||
|
|
||||||||||
| ZHX12 | 7E-5 | 1.2E-5 | 6.2E-5 | 2.0E-2 | ||||||
|
|
||||||||||
| miR-320a | 4.5E-2 | 1.0E-2 | 3.7E-2 | GRAMD1B | 1E-4 | 4.7E-4 | 4.4E-3 | 3.5E-5 | ||
|
|
||||||||||
| KCNMA1 | 7E-5 | 2.4E-2 | 3.4E-2 | 9.1E-5 | ||||||
|
|
||||||||||
| PSTPIP2 | 2E-5 | 1.6E-4 | 7.1E-4 | 1.9E-3 | ||||||
|
|
||||||||||
| miR-424 | 6.7E-3 | 2.4E-2 | 2.7E-2 | GRAMD1B | 1E-4 | 4.7E-4 | 4.4E-3 | 5.9E-3 | ||
|
|
||||||||||
| KCNMA1 | 7E-5 | 2.4E-2 | 3.4E-2 | 9.8E-3 | ||||||
|
|
||||||||||
| PSTPIP2 | 2E-5 | 1.6E-4 | 7.1E-4 | 2.0E-2 | ||||||
|
|
||||||||||
| SHFM3P1 | 2E-6 | 2.8E-3 | 1.2E-2 | 4.0E-2 | ||||||
|
|
||||||||||
| 4E-5 | ||||||||||
Bold miRNA and gene pairs meet negative correlation and p<10−4 cutoff and were evaluated in replication samples.