Table 5.

Multivariable analysis of risk of mortality. Independent variables included in the model were total hours on ECMO, total number of complications, age, timing of fungal infection and support type. Fungal infections as an independent variable conferred an increased odd risk of mortality for the entire cohort in all infection timing subgroups. Significant increases in odds ratio of mortality are indicated in bold typeset. Four distinct infection status categories exist; no infection, infection acquired during ECMO (on-ECMO), previous fungal infection cleared during ECMO (pre-ECMO) and persistent infection throughout ECMO (all-ECMO). OR= Odds Ratio

Age Group	Acquired	Cleared	Persistent
	OR (95% CI)	OR (95% CI)	OR (95% CI)
All Patients	1.46 (1.17–1.82)	2.19 (1.46–3.27)	3.29 (1.19–9.10)
Neonates	2.54 (1.63–3.95)	1.34 (0.62–2.87)	3.35 (0.47–23.7)
Pediatrics	1.43 (1.04–1.97)	2.11 (1.19–3.73)	3.45 (0.92–12.98)
Adults	0.73 (0.48–1.10)	2.91 (1.21–6.97)	1.73 (0.14–21.47)