Appendix 1.

Patient complications and component failure (listed as mechanical complications) encoded in the ESLO registry.

System	Complications
Cardiovascular	Cardiac arrhythmia, CPR required, Hypertension requiring vasodilators, Inotropes on ECLS, Myocardial stun by echo, PDA: bidirectional/ L->R, Tamponade: air/ blood
Hemorrhagic	Cannulation site bleeding, Disseminated intravascular coagulation (DIC), GI hemorrhage, Hemolysis (Hgb > 50 mg/dl), Surgical site bleeding
Infectious	Culture proven infection; WBC < 1,500
Metabolic	Glucose < 40, Glucose > 240, Hyperbilirubinemia (> 2 direct or > 15 total), pH < 7.20 or > 7.60
Neurologic	Brain death clinically determined, CNS hemorrhage by US/CT, CNS infarction by US/CT, Seizures: clinically determined, Seizures: EEG determined
Pulmonary	Pneumothorax requiring treatment, Pulmonary hemorrhage
Renal	CAVHD required, Creatinine > 3.0, Creatinine 1.5 – 3.0, Dialysis required, Hemofiltration required
Mechanical	Cannula problems, Clots: bladder/ bridge/ hemofilter/ other/ oxygenator, Cracks in pigtail connectors, Other tubing rupture, Oxygenator failure, Mechanical: Pump malfunction, Raceway rupture