Skip to main content
. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: J Neurochem. 2012 Jul 27;123(1):124–134. doi: 10.1111/j.1471-4159.2012.07857.x

Table 1.

Dopamine HVA DOPAC HVA/DA DOPAC/DA
WT 129.19 ± 4.50 12.49 ± 0.31 7.25 ± 0.40 9.37 ± 0.26 5.69 ± 0.39
ClockΔ 19 138.66 ± 4.78 15.55 ± 0.53**** 8.78 ± 0.32** 11.35 ± 0.49** 6.24 ± 0.25

Levels of dopamine (DA), HVA and DOPAC were measured in dorsal striatum tissue by HPLC. Values represent means pM/mg tissue ± standard errors. Dopamine levels were not significantly changed in the ClockΔ 19 mice compared with wild type controls (T(23) = 1.435, p = 0.1646). There were significant differences in the metabolites and metabolite ratios. HVA, DOPAC and the ratio of HVA/DA were increased in the ClockΔ 19 mice (**p<0.01, ***p<0.001, and ****p<0.0001, n = 12–13 animals per group).