Table 1.
Most significantly differentially expressed genes in response to LTC4 (1 μM) in LPS-primed human coronary artery SMCs (sorted by fold change)
| Gene ID | Probe ID | Gene name | Mean fold change | Direction | P value |
|---|---|---|---|---|---|
| CSF3 | A_23_P501754 | Colony stimulating factor 3 | 15.88 | Up | 0.04128 |
| IL24 | A_23_P51951 | Interleukin 24 | 15.11 | Up | 0.04918 |
| SERPINB2 | A_23_P153185 | Serine proteinase inhibitor 2 (plasminogen activator inhibitor 2) | 5.46 | Up | 0.03882 |
| NEFM | A_24_P264832 | Neurofilament medium polypeptide | 4.89 | Up | 0.01537 |
| GJA1 | A_23_P93591 | Gap junction protein. Alpha 1 | 4.74 | Up | 0.00931 |
| IL1A | A_23_P72096 | Interleukin 1 alpha | 4.15 | Up | 0.01096 |
| CXCR4 | A_23_P102000 | Chemokine (C-X-C motif) receptor 4 | 3.94 | Up | 0.00170 |
| TFPI2 | A_24_P95070 | Tissue factor pathway inhibitor 2 | 3.90 | Up | 0.02599 |
| CCND1 | A_24_P124550 | Cyclin D1 | 3.28 | Up | 0.04980 |
| CXCL3 | A_24_P183150 | Chemokine (C-X-C motif) ligand 3 | 3.27 | Up | 0.02149 |
| ABCG1 | A_23_P166297 | ATP-binding cassette. Sub-family G. Member 1 | 3.03 | Up | 0.00178 |
| HAS1 | A_23_P27400 | Hyaluronan synthase 1 | 2.85 | Up | 0.03572 |
| MMP3 | A_23_P161698 | Matrix metallopeptidase 3 | 2.70 | Up | 0.01282 |
| PITPNC1 | A_24_P772103 | Phosphatidylinositol transfer protein. Cytoplasmic 1 | 2.55 | Up | 0.03758 |
| KITLG | A_23_P204654 | KIT ligand | 2.49 | Up | 0.00730 |
| FUBP3 | A_23_P435833 | Far upstream element (FUSE) binding protein 3 | 2.46 | Up | 0.00619 |
| NPTX1 | A_23_P124905 | Neuronal pentraxin I | 2.45 | Up | 0.00504 |
| PCSK1 | A_23_P213508 | Proprotein convertase subtilisin/kexin type 1 | 2.41 | Up | 0.04376 |
| ADSS | A_23_P859 | Adenylosuccinate synthase | 2.40 | Up | 0.01023 |
| TFPI2 | A_23_P393620 | Tissue factor pathway inhibitor 2 | 2.38 | Up | 0.01401 |
| NPR3 | A_23_P327451 | Natriuretic peptide receptor C/guanylate cyclase C | 2.33 | Up | 0.01309 |
| SPRED1 | A_23_P54460 | Sprouty-related. Evh1 domain containing 1 | 2.30 | Up | 0.02536 |
| PITPNC1 | A_23_P84189 | Phosphatidylinositol transfer protein. Cytoplasmic 1 | 2.29 | Up | 0.01626 |
| NKAIN1 | A_23_P51376 | Na+/K+ transporting ATPase interacting 1 | 2.26 | Up | 0.02838 |
| SOCS4 | A_24_P90637 | Suppressor of cytokine signaling 4 | 2.23 | Up | 0.00918 |
| TMTC3 | A_24_P944222 | Transmembrane and tetratricopeptide repeat containing 3 | 2.22 | Up | 0.04956 |
| CACNG8 | A_32_P61693 | Calcium channel. Voltage-dependent. Gamma subunit 8 | 2.19 | Up | 0.00480 |
| RRN3 | A_23_P206877 | RNA polymerase I-specific transcription initiation factor RRN3 | 2.15 | Up | 0.00613 |
| APOBEC3F | A_23_P369966 | Apolipoprotein B mRNA editing enzyme. Catalytic polypeptide-like 3F | 2.12 | Up | 0.03633 |
| NFE2L3 | A_24_P136653 | Nuclear factor (erythroid-derived 2)-like 3 | 2.08 | Up | 0.00912 |
| MYH11 | A_24_P70183 | Myosin heavy chain 11 (smooth muscle) | 10.44 | Down | 0.02218 |
| MYH11 | A_23_P206920 | Myosin heavy chain 11 (smooth muscle) | 9.66 | Down | 0.01751 |
| SCRG1 | A_23_P167159 | Stimulator of chondrogenesis 1 | 4.73 | Down | 0.01807 |
| TPD52L1 | A_23_P31143 | Tumor protein D52-like 1 | 4.64 | Down | 0.01830 |
| CARD9 | A_23_P500433 | Caspase recruitment domain family. Member 9 | 3.54 | Down | 0.00009 |
| CLIC3 | A_23_P254654 | Chloride intracellular channel 3 | 3.53 | Down | 0.00765 |
| KRT7 | A_23_P381945 | Keratin 7 | 3.37 | Down | 0.03569 |
| PCK2 | A_23_P128817 | Phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 2.66 | Down | 0.02696 |
| CTAGE1 | A_24_P124805 | Cutaneous T cell lymphoma-associated antigen 1 | 2.57 | Down | 0.01412 |
| GLI1 | A_23_P105251 | GLI family zinc finger 1 | 2.56 | Down | 0.01105 |
| SLC1A7 | A_23_P325562 | Solute carrier family 1. Member 7 | 2.53 | Down | 0.00758 |
| TGM1 | A_23_P65618 | Transglutaminase 1 | 2.45 | Down | 0.00203 |
| IL17RD | A_32_P188860 | Interleukin 17 receptor D | 2.39 | Down | 0.01570 |
| ZNF467 | A_23_P59470 | Zinc finger protein 467 | 2.19 | Down | 0.00619 |
| LIMS2 | A_23_P142796 | LIM and senescent cell antigen-like domains 2 | 2.05 | Down | 0.01940 |
Note that some genes may be listed twice due to significant differences detected by independent probes