Fig. 4.

Example images of Nr4a1 (a), Egr1 (b), c-fos (c) and Id1 (d) mRNA expression as assessed by ISH (up) and quantification results for mRNA expression of these genes in the CCX in groups treated for 3 days with CIT repeatedly and in a single dose (down). Data represent the mean optical density±SEM (PSL/mm²) normalized to the control. Student’s t test was used as post hoc test to compare the 3-day-treated groups vs the control group; *p < 0.05