Figure 5.

Hippo pathway regulates Dronc activity levels to control growth and apoptosis. Co-expression of Dark and proDronc with UASGFP (magenta in a) (GMR-Gal4 UASGFP, UASDark, UASproDronc) induces (a) Dronc (greyscale), and (b) activated Caspase 3 (Casp3*) in eyeantennal imaginal discs, resulting in development of small eyes in adult flies (c). The effect of co-expression of Dark and Dronc with Hpo (GMR-Gal4 UASHpo, UASDark, UASproDronc) (d–f) and Yki (GMR-Gal4 UASYki, UASDark, UASproDronc) (g–i) on the expression of Dronc (d and g), and Casp3* (e and h) in eyeantennal imaginal discs and in adult eyes (f and i) is shown. Magnification and orientation of images is identical in all panels. The color reproduction of this figure is available at the Cell Death and Differentiation journal online