Figure 7.

Loss of Caspase-2 promotes dissemination of Eμ-Myc lymphomas. (a) Representative images of H&E-stained sections from lung (left panel) and spleen (right panel) from mice of the indicated genotypes showing tumor manifestation ( × 400 magnification). (b) Percentage of tumor infiltrated area in indicated organs and genotypes quantified from H&E-stained sections of n>6 mice per genotype. Data are represented as mean values±S.E.M. *^,§Indicate significant difference with a P-value of <0.05 comparing Eμ-Myc/Casp2^−/− with Eμ-Myc or Eμ-Myc/Pidd^−/− mice, respectively