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. Author manuscript; available in PMC: 2013 Sep 6.
Published in final edited form as: Neuron. 2012 Sep 6;75(5):824–837. doi: 10.1016/j.neuron.2012.06.024

Figure 3. JNK3 activity is increased in human AD and FAD cases.

Figure 3

(A) JNK3 activity is increased in human AD cases compared to age-matched controls. The lysates from human frontal cortices were subjected to JNK3 immunoprecipitation/kinase assays using GST-c-jun as a substrate. As a control, JNK3 and 6E10 Western blots are also shown.

(B) Quantification of 32P-GST-c-jun in (A). The data are represented as means ± SEM.

(C) JNK3 activity is higher in FAD mice compared to normal mice at 5-6 months. Lanes 1 to 4 represent four different FAD:JNK3+/+ mice, and lanes 5 to 8, JNK3+/+ mice.

(D) Quantification of 32P-GST-c-jun in (C). The data are represented as means ± SEM.