Table IV.
Genotype and allele frequencies of CYP11B2, CYP17A1, CYP2B6, CYP2C9, CYP2E1 and CYP7A1 polymorphisms in IS patients according to smoking status.
| Gene
|
Genotype | Smoking (−)
|
Smoking (+)
|
Model | OR (95% CI) | p-value | pc | ||
|---|---|---|---|---|---|---|---|---|---|
| SNP | n | % | n | % | |||||
| CYP11B2 | T/T | 51 | 56.7 | 17 | 58.6 | Codominant 1 | 0.55 (0.19–1.56) | 0.34 | 1.00 |
| rs1799998 | T/C | 38 | 42.2 | 8 | 27.6 | Codominant 2 | 10.51 (0.73–150.38) | 0.26 | 1.00 |
| −344 | C/C | 1 | 1.1 | 4 | 13.8 | Dominant | 0.76 (0.29–2.01) | 0.57 | 1.00 |
| Recessive | 14.00 (1.03–190.90) | 0.0220 | 0.13 | ||||||
| Log-additive | 1.19 (0.53–2.65) | 0.67 | 1.00 | ||||||
| CYP17A1 | T/T | 50 | 55.6 | 16 | 55.2 | Codominant 1 | 1.02 (0.38–2.71) | 0.98 | 1.00 |
| rs2486758 | T/C | 34 | 37.8 | 11 | 37.9 | Codominant 2 | 0.63 (0.11–3.83) | 0.96 | 1.00 |
| −190 | C/C | 6 | 6.7 | 2 | 6.9 | Dominant | 0.94 (0.37–2.37) | 0.89 | 1.00 |
| Recessive | 0.63 (0.11–3.63) | 0.60 | 1.00 | ||||||
| Log-additive | 0.89 (0.43–1.82) | 0.74 | 1.00 | ||||||
| CYP2B6 | C/C | 54 | 60.0 | 21 | 72.4 | Codominant 1 | 0.53 (0.19–1.48) | 0.35 | 1.00 |
| rs4802100 | G/C | 32 | 35.6 | 8 | 27.6 | Codominant 2 | 0.00 (0.00-NA) | ||
| −1180 | G/G | 4 | 4.4 | 0 | 0.0 | Dominant | 0.47 (0.17–1.29) | 0.13 | 0.78 |
| Recessive | 0.00 (0.00-NA) | ||||||||
| Log-additive | 0.45 (0.18–1.15) | 0.08 | 0.49 | ||||||
| CYP2C9 | T/T | 34 | 37.8 | 12 | 41.4 | Codominant 1 | 1.19 (0.44–3.26) | 0.74 | 1.00 |
| rs4918758 | T/C | 43 | 47.8 | 13 | 44.8 | Codominant 2 | 1.21 (0.29–5.16) | 0.84 | 1.00 |
| −1163 | C/C | 13 | 14.4 | 4 | 13.8 | Dominant | 1.20 (0.46–3.08) | 0.71 | 1.00 |
| Recessive | 1.11 (0.29–4.27) | 0.88 | 1.00 | ||||||
| Log-additive | 1.12 (0.57–2.20) | 0.73 | 1.00 | ||||||
| CYP2E1 | G/G | 51 | 56.7 | 24 | 82.8 | Codominant 1 | 0.42 (0.13–1.35) | 0.15 | 0.90 |
| rs3813867 | G/C | 32 | 35.6 | 5 | 17.2 | Codominant 2 | 0.00 (0.00-NA) | ||
| −1272 | C/C | 7 | 7.8 | 0 | 0.0 | Dominant | 0.28 (0.09–0.87) | 0.0190 | 0.11 |
| Recessive | 0.00 (0.00-NA) | ||||||||
| Log-additive | 0.30 (0.11–0.79) | 0.0056 | 0.0336 | ||||||
| CYP7A1 | T/T | 29 | 32.2 | 9 | 31.0 | Codominant 1 | 1.50 (0.51–4.41) | 0.10 | 0.60 |
| rs3808607 | T/G | 42 | 46.7 | 13 | 44.8 | Codominant 2 | 1.78 (0.49–6.46) | 0.77 | 1.00 |
| −278 | G/G | 19 | 21.1 | 7 | 24.1 | Dominant | 1.59 (0.58–4.33) | 0.36 | 1.00 |
| Recessive | 1.41 (0.46–4.31) | 0.55 | 1.00 | ||||||
| Log-additive | 1.35 (0.71–2.54) | 0.36 | 1.00 | ||||||
IS, ischemic stroke; SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval; NA, not applicable; pc, For multiple comparisons, the Bonferroni correction was performed by multiplying the p-value by the number of SNPs analyzed (n=6). The p-values were calculated from logistic regression analysis. Bold numbers indicate significant associations.