Table II.

Genotype and allele frequencies of DHFR SNPs in the childhood acute lymphoblastic leukemia (ALL) cases and controls, and association with risk of ALL.

Modela	Genotype	ALL cases (n=70)	Controls (n=100)	p-valueb	OR	95% CI	p-valuec	p-value HWE
-A317G (rs408626)
Co	A/A	14 (20.00)	36 (35.00)	0.037e	1.00			0.152d
	A/G	33 (47.14)	42 (43.57)		2.24	1.03–4.88	0.042e
	G/G	23 (32.86)	22 (21.43)		2.89	1.22–6.86	0.016e
Do	A/A	14 (20.00)	36 (35.00)		1.00
	A/G + G/G	56 (80.00)	64 (65.00)		2.47	1.19–5.11	0.015e
Re	A/A + AG	47 (67.14)	78 (78.57)		1.00
	G/G	23 (32.86)	22 (21.43)		1.74	0.87–3.45	0.116
	Allele
	A	61 (43.57)	114 (57.00)	0.011e	1.00
	G	79 (56.43)	86 (43.00)		1.73	1.12–2.68	0.014e
C829T (rs34764978)
Co	C/C	10 (14.29)	33 (33.00)	0.016e	1.00			0.077d
	C/T	53 (75.71)	56 (56.00)		2.83	1.27–6.33	0.011e
	T/T	7 (10.00)	11 (11.00)		1.97	0.60–6.46	0.261
Do	C/C	10 (14.29)	33 (33.00)		1.00
	C/T + T/T	60 (85.71)	67 (67.00)		2.69	1.22–5.95	0.014e
Re	C/C + C/T	63 (90.00)	89 (89.00)		1.00
	T/T	7 (10.00)	11 (11.00)		0.89	0.33–2.44	0.835
	Allele
	C	73 (52.14)	122 (61.00)	0.119	1.00
	T	67 (47.86)	78 (39.00)		1.38	0.89–2.12	0.151

Data indicate n (%).

^aGenetic model: Co, codominant, Do, dominant, Re, recessive.

^bObtained by the Chi-square test.

^cObtained by the logistic regression analysis, taking reference to AA and CC genotypes;

^dHWE (Hardy-Weinberg equilibrium) to controls. OR, odds ratio; 95% CI, 95% confidence interval.

^eSignificant p<0.05.