Table IV.
Association of the -A317G and C829T polymorphisms in the DHFR gene and other clinical features with the risk of relapse of childhood acute lymphoblastic leukemia.
| Modela | Genotype | No. (%) | OR | 95% CI | p-valueb |
|---|---|---|---|---|---|
| -A317G (rs408626) | |||||
| Co | A/A | 14 (20.00) | 1.00 | ||
| A/G | 33 (47.14) | 4.80 | 1.26–18.24 | 0.021c | |
| G/G | 23 (32.86) | 8.55 | 1.84–39.70 | 0.006c | |
| Do | A/A | 14 (20.00) | 1.00 | ||
| A/G + G/G | 56 (80.00) | 7.62 | 2.01–28.81 | 0.003c | |
| Re | A/A + AG | 47 (67.14) | 1.00 | ||
| G/G | 23 (32.86) | 2.94 | 0.86–10.06 | 0.084 | |
| C829T (rs34764978) | |||||
| Co | C/C | 10 (14.29) | 1.00 | ||
| C/T | 53 (75.71) | 6.50 | 1.47–28.67 | 0.013c | |
| T/T | 7 (10.00) | 14.00 | 1.13–172.63 | 0.039c | |
| Do | C/C | 10 (14.29) | 1.00 | ||
| C/T + T/T | 60 (85.71) | 7.00 | 1.60–30.54 | 0.010c | |
| Re | C/C + C/T | 63 (90.00) | 1.00 | ||
| T/T | 7 (10.00) | 3.00 | 0.348–26.55 | 0.323 | |
| Gender | |||||
| Female | 25 (35.71) | 1.00 | |||
| Male | 45 (64.29) | 1.38 | 0.49–3.92 | 0.540 | |
| Risk by age | |||||
| 1–9 years (low risk) | 18 (25.71) | 1.00 | |||
| <1 and >9 years (high risk) | 52 (74.29) | 4.54 | 1.14–18.09 | 0.032c | |
| Leukocytes at diagnosis | |||||
| <50,000/mm3 | 18 (25.71) | 1.00 | |||
| >50,000/mm3 | 52 (74.29) | 7.64 | 1.90–30.73 | 0.004c |
a
Genetic model: Co, codominant; Do, dominant; Re, recessive.
b
Obtained by logistic regression analysis;
c
Significant p<0.05; OR, odds ratio; 95% CI, 95% confidence interval.