Table I.
Stroke-induced miRNAs.
| Authors, year (ref.) | Sample source/type of stroke | Regulation | miRNAs aberrantly expressed | Notes |
|---|---|---|---|---|
| Jeyaseelan et al, 2008 (20) | Male SD rat blood and brain, transient focal ischemia by MCAO | Up | (24 h) miR-16, -23a, -103, -107, -150, -185, -191, -292-5p, -320, -451, -494 and let-7 (a, d, f and i) | Screening of blood and brain samples at 24 and 48 h after reperfusion. |
| (48 h) miR-26a, -26b, -103, -107, -140*, -150, -185, -195, -191, -214, -320, -328, -352, -494 and let-7 (a, c and i) | miRNAs whose expression changed by >1-fold are presented. | |||
| Down | (both 24 and 48 h) miR-7, -27a, -29b,c, -30e,- 98, -101a, -137, -148b, -204, -218, -301, -338, -335, -365-5p, -376b,b* | |||
| Dharap et al, 2009 (21) | Adult male spontaneously hypertensive rat brain, transient focal ischemia by MCAO | Up | miR-140,-145,-331 | MCAO 1 h |
| Down | miR-376b-5p, -153, -29c, -98, -204 | Screening of blood samples at 3, 6, 12, 24 and 72 h. | ||
| The miRNAs presented had fold changes at all time points. | ||||
| Tan et al, 2009 (22) | Human peripheral whole blood, ischemic stroke | Up | Has-let-7e, miR-1184, -1246, -1261, 1275, -1285, -1290, -181a, -25*, -513a-5p, -550, 602, -665, -891, -933,-923 | Ischemic patients between 18-49 years of age of all subtypes (LA, SA, CEmb and UND). miRNAs whose expression changed by >1-fold are presented. |
| Down | Has-let-7f, miR-126, -1259, -142-3p, -15b, -186, -519e, -768-5p | |||
| Liu et al, 2001 (23) | Male SD rat brain and blood, three different injuries | Up | (brain) miR-542-3p | Focal ischemia, intracerebral hemorrhage and Kainate seizures. |
| (blood) miR-96, -152, 298, -333, -505 | ||||
| Down | (brain) miR-155, 362-3p, -122, -450a-5p | miRNAs in all three conditions were regulated by >2-fold. | ||
| (blood) miR-125a-5p, -130b, -142-3p, -330, -342-5p, -685, -347 | ||||
| Lee et al, 2001 (26) | Male C57BL/6 mice brain, ischemic preconditioning | Up | (3 h) miR-200a,b,c, miR-141, -429, -182, -183, 96 | Ischemic preconditioning for 15 min. Screening of miRNA expression after reperfusion of 3 and 24 h. |
| (24 h) miR-681, 197 | ||||
| Down | (3 h) no down-regulated miRNAs | |||
| (24 h) miR-468 | miRNAs whose expression was changed by >1-fold are presented. | |||
| Dharap and Vemuganti, 2010 (27) | Adult male spontaneously hypertensive rat brain, ischemic preconditioning | Up | miR-374, 98, -340, -5p, -21, -352, -37*, -335, -181b, -26b,- 181b, -15b, -146a, let-7a | Preconditioning for 10 min, reperfusion at 6, 24 and 72 h. |
| Down | miR-466c, -292-5p, -328, -873, -494, -345-5p, -92b, -30c-2*, 322*, let-7d* | miRNAs whose expression was changed by >1.5-fold at all of the three time points. |
SD, Sprague-Dawley rat; MCAO, middle cerebral ischemia artery occlusion; LA, large artery stroke; SA, small artery stroke; CEmb, cardioembolic stroke; UND, undetermined cause.