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. 2012 Jul 18;32(29):9835–9847. doi: 10.1523/JNEUROSCI.0638-12.2012

Figure 1.

Figure 1.

PDGF-BB reverses HIV-1 Tat–cocaine-mediated impairment of proliferation of NPCs. Effect of Tat (A), cocaine (B), and PDGF-BB (C) on NPC proliferation. All the data in these figures are presented as mean ± SD of four individual experiments. *p < 0.05, **p < 0.01 versus control group. D, PDGF-BB restored Tat–cocaine-mediated impairment of NPC proliferation. E, Representative microscopic images showing BrdU labeling in control (left), Tat–cocaine-treated (middle), and PDGF-BB plus Tat–cocaine-treated (right) NPCs. Red, BrdU; blue, DAPI. Scale bars, 10 μm. F, Effect of cocaine and/or Tat on NPC survival as determined by MTT assay. G, Effect of cocaine and/or Tat on the cytotoxicity of NPC using LDH assay. H, Effect of cocaine and/or Tat on the cytotoxicity of NPC using TUNEL assays. I, Representative microscopic images showing TUNEL-positive cells in control, Tat-treated, cocaine-treated, and cocaine–Tat-treated NPCs. Green, TUNEL; blue, DAPI. Scale bars, 20 μm. All the data in these figures are presented as mean ± SD of four individual experiments. **p < 0.01, ***p < 0.001 versus control group; ###p < 0.001 versus Tat–cocaine group.