. 2011 Oct 18;3(1):134–140. doi: 10.3892/etm.2011.368

Table IV.

Summary of quality of life (QOL) scales – one-sided p-value (12–17 weeks).

Authors/(Refs.)	Test	Treatment	Global QOL	Fatigue	Nausea and vomiting	Pain	Dyspnoea	Insomnia	Appetite loss	Constipation
	Combining p-value of inverse normal method^d		0.016	0.007	<0.001	0.160	0.360	0.140	0.027	0.001


Rosell et al (21)	Wei Johnson test of stochastic ordering	CDDP	(0.939)	(0.955)	(0.149)	0.971	(0.163)	(0.985)		(0.468)
Rosell et al (21)	Wei Johnson test of stochastic ordering	CBDCA							0.042^a
Scagliotti (22)	One-way ANOVA^b	CDDP	-	0.910		-	-	-	0.750	-
Scagliotti (22)	One-way ANOVA^b	CBDCA			0.003^a
Danson et al (23)	-^b	CDDP					0.992	0.990	0.998
Danson et al (23)	-^b	CBDCA	0.015^a	0.001^a	<0.001^a	0.045^a				0.001^a
Paccagnella et al (24)	Repeated measure ANOVA	CDDP	(0.400)	(0.150)		(0.470)	(0.170)
Paccagnella et al (24)	Repeated measure ANOVA	CBDCA			<0.001^a			0.015^a	0.005^a	0.005^a
Rudd et al (25)	Mann-Whitney U test^c	CDDP				(0.720)		0.840	(0.750)	(0.250)
Rudd et al (25)	Mann-Whitney U test^c	CBDCA	0.060^a	0.095^a	0.020^a		0.290^a
Booton et al (26)	Mann-Whitney U test^b	CDDP		(0.999)			(0.999)	0.995
Booton et al (26)	Mann-Whitney U test^b	CBDCA	0.500^a		0.009^a	0.500^a			0.500^a	0.500^a

CDDP, cisplatin; CBDCA, carboplatin; p-value, two-sided p-value. One-sided p-value could not be calculated since the direction (positive or negative) was not reported.

One-sided p-value, in favour of CBDCA.

Two-sided p-value was calculated by t-test using scores of QOL scale since the p-value of the difference from the regimens was not provided in the literature [Booton (26): two-sided p-value in nausea and vomiting was provided in the literature].

We decided whether the result was negative or positive using the median and interquartile ranges that were reported in the trial.

p<0.05 reflects a favorable outcome in CBDCA arm. Numbers in bold indicate the scale of a favorable outcome in CBDCA arm.