Figure 3.

OPLS-DA models based on ¹H NMR spectra of plasma from patients with CSCC or CIN and healthy controls. (A) Separation between CIN and healthy controls; ▪ healthy controls; ▴ CIN. (B) Separation between CSCC and healthy controls; ▪ healthy controls; ▴ CSCC. (C) Separation between CIN and CSCC; ▪ CIN; ▴ CSCC. Model parameters were R2X=0.434, R2Y=0.668, Q2=0.569; R²X=0.34, R²Y=0.87, Q2=0.83; R²X=0.31, R2Y=0.89, Q²=0.84, respectively. OPLS-DA, orthogonal partial least-squares discriminant analysis; NMR, nuclear magnetic resonance; CSCC, cervical squamous cell carcinoma; CIN, cervical intraepithelial neoplasia.