Figure 1.

Tumor volume changes in human non-small cell lung cancer, (A) Lu-99 and (B) PC-9 cell lines, in vivo. Mice were randomized according to the tumor volumes on day 0. The mice implanted with tumors from Lu-99 and PC-9 cells were treated with the vehicle or S-1 at 8.3 or 10 mg/kg administered orally once daily on days 1–14. Erlotinib at 100 or 12.5 mg/kg, was administered orally, alone or in combination with S-1 on days 1–14. The tumor volume was measured twice a week. The values indicate the means ± SD of the RTV (n=6). ^*Overall maximal P<0.05 according to a closed testing procedure using the Aspin-Welch t-test. RTV, relative tumor volume. S-1, tegafur-gimeracil-oteracil.