Figure 2.

Tumor volume changes in (A) human breast cancer MX-1 cell line and (B) NSCLC NCI-H460 cell line, in vivo. Mice were treated with the vehicle or S-1 at 8.3 mg/kg. Sorafenib at 15 mg/kg was administered orally once daily on days 1-14, alone or in combination with S-1. The values indicate the means ± SD of the RTV (n=8). ^**Overall maximal P<0.01 according to a closed testing procedure using the Aspin-Welch t-test. NSCLC, non-small cell lung cancer; RTV, relative tumor volume. S-1, tegafur-gimeracil-oteracil.