Figure 4.

Tumor volume changes in human colorectal cancer, (A) Col-1 and (B) KM20C cell lines, in vivo. Mice were treated with the vehicle (○) or S-1 at 6.9 mg/kg once daily on days 1–14 orally. Bevacizumab at 5 mg/kg was administered intraperitoneally on days 1, 4, 8 and 11, alone or with S-1. The tumor volume was measured twice a week. The values indicate the means ± SD of the RTV (n=7). ^**Overall maximal P<0.01 according to a closed testing procedure using the Aspin-Welch t-test. RTV, relative tumor volume. S-1, tegafur-gimeracil-oteracil.