Figure 5.

Tumor volume changes in human colorectal cancer, (A) DLD-1, and (B) KM12C/5-FU cell lines, in vivo. Mice were treated with the vehicle or S-1 at 6.9 mg/kg once daily on days 1–14 orally. Cetuximab (40 mg/kg) was intraperitoneally administered on days 1, 4, 8 and 11 alone or with S-1. The tumor volume was measured twice a week. The values indicate the means ± SD of the RTV (n=7). ^**Overall maximal P<0.01 according to a closed testing procedure using the Aspin-Welch t-test. RTV, relative tumor volume. S-1, tegafur-gimeracil-oteracil.