Table 3.
Expression of angiogenesis-related biomarkers in UTUC associated with BEN and in control UTUC
| Molecular marker | N 110 | BEN (N = 50) | Control (N = 60) | p < |
|---|---|---|---|---|
| Expression N (%) | ||||
| VEGF | N.S. | |||
| Not altered | 32 (29.1) | 16 (32.0) | 16 (26.7) | |
| Altered | 78 (70.9) | 34 (68.0) | 44 (73.3) | |
| VEGFR1 | 0.005 | |||
| Not altered | 38 (34.5) | 25 (50.0) | 13 (21.7) | |
| Altered | 72 (65.5) | 25 (50.0) | 47 (78.3) | |
| VEGFR2 | NS | |||
| Not altered | 81 (73.6) | 35 (70.0) | 46 (76.7) | |
| Altered | 29 (26.4) | 15 (30.0) | 14 (23.3) | |
| MVD CD31* | N.S. | |||
| X± SD | 5.02±9.06 | 5.46±8.85 | 4.66±9.3 | |
| MVD CD34* | N.S. | |||
| X± SD | 22.46±10.68 | 22.23±9.30 | 22.65±11.79 | |
| HIF 1α | N.S. | |||
| Not altered | 60 (54.5) | 25 (50.0) | 35 (58.3) | |
| Altered | 50 (45.5) | 25 (50.0) | 25 (41.7) | |
χ2 test was performed.
*
Mann Whitney U test was performed.
N.S. - no significance