Table 2.
Hepatocellular adenoma in Japan: a comparison with previous reports.
| Sasaki et al., 2011 [10]* | Konishi et al., 1995 [9] | Lin et al., 2011 [11] | Bioulac-Sage et al., 2009 [3] | |
|---|---|---|---|---|
| (n = 13) | (n = 58) | (n = 191) | (n = 128) | |
| Age; mean (range) | 41 (15–68) | 34 | 39 (5–79) | 41 (21–66) |
| Female | 54% | 62% | 38% | 91% |
| Oral contraceptives | 29% | 8% | 4.2% | 78% |
| Alcohol >40 g/day | 15% | nd | nd | 12% |
| BMI >25 | 15% | nd | nd | 33% |
| Tumor size; mean (range) (cm) | 5.3 (1.5–19) | 11.3 | 8.3 (2–31) | 7 (1–18) |
| Multiple | 46% | 16% | 6% | 39% |
| Association of HCC | 8% | 2% | 6% | 4% |
|
| ||||
| HNF1α-inactivated: 15% | HNF1α-inactivated: 38% | |||
| Subtypes | β-catenin-activated: 15 | nd | nd | β-catenin-activated: 6% |
| IHCA: 39% | IHCA: 52% | |||
| Unclassified: 31% | Unclassified: 5% | |||
HNF1α: hepatocyte nuclear factor 1α; IHCA: inflammatory hepatocellular adenoma; BMI: body mass index; *with modification.