Table 1.

List of variables used in modeling.

Variable	Description	Unit
c g	Glucose concentration	mM
c lac	Lactate concentration	mM
Q g	Glucose uptake rate	mol/cell/sec
Q lac	Lactate production rate	mol/cell/sec
Q ATP	ATP production rate	mol/cell/sec
k l	Cell proliferation time	1/h
L	Number of living cells in certain unit volume	cells/cm3
R	Radius of tumor spheroid	cm
V	Tumor growth velocity	cm/h
T	Growth time	h