Table V.
Clinicopathological profile of the curatively resected CRC patients in the periods 1990–1999 and 2000–2009.
| Period
|
|||
|---|---|---|---|
| Variable | 1990–1999 (n=835) (%) | 2000–2009 (n=1,247) (%) | P-value |
| Gender | |||
| Male | 555 (66) | 782 (63) | 0.08 |
| Female | 280 (34) | 465 (37) | |
| Age (years) | |||
| Mean ± SD | 62.2±11.0 | 65.5±11.0 | <0.0001 |
| ECOG performance status | |||
| 0 | 765 (92) | 1,129 (91) | 0.98 |
| 1 | 54 (7) | 89 (7) | |
| 2 | 12 (1) | 19 (2) | |
| 3 | 2 (0) | 5 (0) | |
| 4 | 2 (0) | 5 (0) | |
| Location of primary cancera | |||
| Right-sided colon | 164 (20) | 325 (26) | 0.0008 |
| Left-sided colon | 319 (38) | 400 (32) | |
| Rectum | 352 (42) | 522 (42) | |
| Histological type | |||
| Differentiated | 771 (92) | 1,173 (94) | 0.50 |
| Undifferentiated | 55 (7) | 74 (6) | |
| Unknown | 9 (1) | 0 (0) | |
| Maximum tumor diameter (mm)b | |||
| Mean ± SD | 43.8±24.3 | 40.9±22.8 | 0.005 |
| Depth | |||
| T0c | 35 (4) | 52 (4) | 0.06 |
| T1 | 104 (12) | 212 (17) | |
| T2 | 121 (14) | 208 (17) | |
| T3 | 528 (63) | 746 (60) | |
| T4 | 27 (3) | 49 (4) | |
| Regional lymph node metastasis | |||
| N0 | 519 (62) | 806 (65) | 0.19 |
| N1 | 210 (25) | 297 (24) | |
| N2 | 64 (8) | 112 (9) | |
| N3 | 20 (2) | 17 (1) | |
| Distant metastasis | |||
| M0 | 786 (94) | 1,129 (91) | 0.003 |
| M1 | 49 (6) | 118 (9) | |
| Initial UICC stage | |||
| 0c | 37 (4) | 48 (4) | 0.001 |
| I | 194 (23) | 348 (28) | |
| II | 300 (36) | 389 (31) | |
| III | 255 (31) | 344 (28) | |
| IV | 49 (6) | 118 (9) | |
| Family history of CRC | |||
| Absent | 782 (94) | 1,135 (91) | 0.01 |
| Present | 48 (5) | 109 (9) | |
| Unknown | 5 (1) | 4 (0) | |
| Smoking habit | |||
| Never smoked | 373 (45) | 550 (44) | 0.73 |
| Current or ex-smoker | 457 (54) | 695 (56) | |
| Unknown | 5 (1) | 3 (0) | |
a
Location of more advanced case was counted in cases of multiple CRC.
b
Excludes cases in which data were not available.
c
Includes cases of CRC after preoperative chemoradiation for primary cancer. CRC, colorectal cancer.