. 2012 Sep;16(9):1086–1091. doi: 10.1089/gtmb.2012.0050

Table 2.

Pooled Analyses of the Epidermal Growth Factor 61A>G Polymorphism on Hepatocellular Carcinoma Risk

			G-allele vs. A-allele				GG vs. AA				GA vs. AA				GG+GA vs. AA				GG vs. GA+AA
	No. of studies	Cases/Controls	OR (95% CI)	P_h	I²,%	p-Value	OR (95% CI)	P_h	I²,%	p-Value	OR (95% CI)	P_h	I²,%	p-Value	OR (95% CI)	P_h	I²,%	p-Value	OR (95% CI)	P_h	I²,%	p-Value
Healthy controls	3	521/514	1.06 (0.88–1.29)	0.86	0	0.52	1.56 (0.96–2.55)	0.70	0	0.07	1.76 (1.07–2.90)	0.72	0	0.02	1.65 (1.03–2.66)	0.70	0	0.04	0.97 (0.76–1.23)	0.90	0	0.78
Controls with liver diseases	6	690/1419	1.49 (1.28–1.73)	0.31	16	<0.001	2.46 (1.75–3.45)	0.70	0	<0.001	1.51 (1.09–2.11)	0.64	0	0.01	1.85 (1.35–2.52)	0.71	0	<0.001	1.59 (1.29–1.96)	0.17	36	<0.001
Ethnicities
Asian	3	521/444	1.33 (1.10–1.62)	0.38	0	0.004	2.15 (1.31–3.53)	0.54	0	0.002	1.74 (1.06–2.86)	0.86	0	0.03	1.93 (1.20–3.12)	0.72	0	0.007	1.35 (1.05–1.74)	0.32	13	0.02
Caucasian	3	169/975	1.76 (1.38–2.26)	0.61	0	<0.001	2.76 (1.73–4.42)	0.53	0	<0.001	1.35 (0.87–2.11)	0.29	19	0.18	1.79 (1.19–2.69)	0.34	9	0.005	2.28 (1.58–3.30)	0.85	0	<0.001
Etiologies
HBV	3	521/444	1.33 (1.10–1.62)	0.38	0	0.004	2.15 (1.31–3.53)	0.54	0	0.002	1.74 (1.06–2.86)	0.86	0	0.03	1.93 (1.20–3.12)	0.72	0	0.007	1.35 (1.05–1.74)	0.32	13	0.02
HCV	2	125/898	1.77 (1.34–2.34)	0.32	0	<0.001	2.72 (1.60–4.62)	0.26	20	<0.001	1.46 (0.87–2.44)	0.14	54	0.15	1.88 (1.17–3.02)	0.16	50	0.009	2.18 (1.45–3.27)	0.81	0	<0.001
Alcohol	1	44/77	1.75 (1.03–2.97)	NA	NA	0.04	2.92 (1.06–8.06)	NA	NA	0.04	1.07 (0.44–2.60)	NA	NA	0.88	1.52 (0.68–3.42)	NA	NA	0.31	2.80 (1.17–6.73)	NA	NA	0.02

P_h, p-value of Q-test for heterogeneity test; NA, data not available; OR, odds ratio; CI, confidence interval.