Table II.
Effects of Ephedra sinica on biochemical parameters in obese diabetic mice.
Normal | Control | Acarbose | Ephedra | |
---|---|---|---|---|
Fasting blood glucose (mg/dl) | ||||
Week 1 | 61.1±9.80 | 61.3±3.70 | 57.3±13.60 | 56.8±16.60 |
Week 3 | 63.5±10.30e | 79.7±13.00b | 67.4±11.50 | 53.3±5.70f |
Week 6 | 60.6±10.20e | 82.8±18.20b | 80.8±10.20b | 56.2±9.70f |
Oral glucose tolerance test (mg/dl) | ||||
0 min | 60.6±10.20e | 82.8±18.20b | 80.8±10.20b | 56.2±9.70f |
30 min | 179.1±44.30 | 224.6±66.20 | 176.1±27.20 | 138.6±18.50f |
60 min | 165.6±38.00d | 216.6±50.80a | 132.0±33.70f | 102.8±16.80f |
Lipid profile (mg/dl) | ||||
Total cholesterol | 142.6±24.50 | 146.3±25.50 | 114.1±14.70 | 197.7±14.40c,f |
TG | 176.3±37.50a | 233.0±59.70 | 135.0±43.60d | 129.6±28.10e |
HDL-cholesterol | 131.6±14.40 | 109.1±29.50 | 113.7±15.70 | 149.9±22.20e |
TG/HDL ratio | 1.35±0.23f | 2.51±0.81c | 1.19±0.40f | 0.87±0.19f |
AST (mg/dl) | 116.8±20.07 | 133.12±30.12 | 91.2±25.86d | 90.8±16.83d |
ALT (mg/dl) | 27.9±4.70f | 39.1±6.41c | 23.9±4.81f | 25.1±4.38f |
Results are presented as the means ± SD. Normal, normal diet-fed mice; control, Surwit's high-fat and high-glucose diet-fed mice; acarbose, Surwit's high-fat and high-glucose diet containing acarbose-fed mice; Ephedra, Surwit's high-fat and high-glucose diet containing Ephedra-fed mice. AST, aspartate transaminase; ALT, alanine transaminase.
p<0.05,
p<0.01,
p<0.001 compared to the normal group;
p<0.05,
p<0.01,
p<0.001 compared to the control group.