Table II.
Genotype frequencies of polymorphisms of the PARD3 gene in schizophrenia patients and control subjects.
| Control
|
Schizophrenia
|
|||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Genotype | n | % | n | % | Model | OR (95% CI) | P-value |
| rs7075263 | T/T | 274 | 78.1 | 156 | 76.8 | Codominant 1 | 0.96 (0.62–1.48) | 0.85 |
| intron | C/T | 75 | 21.4 | 40 | 19.7 | Codominant 2 | 6.00 (1.21–29.68) | 0.028 |
| C/C | 2 | 0.6 | 7 | 3.5 | Dominant | 1.09 (0.72–1.66) | 0.68 | |
| Recessive | 6.06 (1.23–29.87) | 0.014 | ||||||
| Log-additive | 1.22 (0.84–1.77) | 0.30 | ||||||
| rs10827392 | T/T | 281 | 80.1 | 157 | 77.3 | Codominant 1 | 1.11 (0.72–1.72) | 0.63 |
| intron | C/T | 69 | 19.7 | 42 | 20.7 | Codominant 2 | 7.50 (0.82–68.89) | 0.08 |
| C/C | 1 | 0.3 | 4 | 2.0 | Dominant | 1.20 (0.78–1.84) | 0.40 | |
| Recessive | 7.32 (0.80–67.16) | 0.044 | ||||||
| Log-additive | 1.28 (0.86–1.91) | 0.22 | ||||||
| rs773970 | G/G | 108 | 32.1 | 55 | 28.8 | Codominant 1 | 1.36 (0.91–2.04) | 0.14 |
| intron | A/G | 169 | 50.3 | 116 | 60.7 | Codominant 2 | 0.63 (0.34–1.16) | 0.14 |
| A/A | 59 | 17.6 | 20 | 10.5 | Dominant | 1.16 (0.79–1.72) | 0.44 | |
| Recessive | 0.52 (0.30–0.89) | 0.014 | ||||||
| Log-additive | 0.90 (0.68–1.18) | 0.44 | ||||||
| rs2252655 | A/A | 88 | 26.0 | 47 | 23.4 | Codominant 1 | 1.34 (0.87–2.07) | 0.18 |
| intron | A/G | 167 | 49.4 | 121 | 60.2 | Codominant 2 | 0.71 (0.41–1.22) | 0.22 |
| G/G | 83 | 24.6 | 33 | 16.4 | Dominant | 1.13 (0.75–1.71) | 0.56 | |
| Recessive | 0.58 (0.37–0.91) | 0.016 | ||||||
| Log-additive | 0.87 (0.67–1.13) | 0.29 | ||||||
| rs10763984 | C/C | 87 | 24.8 | 49 | 24.3 | Codominant 1 | 1.21 (0.79–1.86) | 0.37 |
| intron | C/T | 174 | 49.6 | 122 | 60.4 | Codominant 2 | 0.61 (0.35–1.04) | 0.07 |
| T/T | 90 | 25.6 | 31 | 15.3 | Dominant | 1.01 (0.67–1.52) | 0.97 | |
| Recessive | 0.53 (0.34–0.84) | 0.005 | ||||||
| Log-additive | 0.80 (0.62–1.04) | 0.10 | ||||||
| rs3781128 | C/C | 130 | 37.4 | 94 | 47.7 | Codominant 1 | 0.65 (0.45–0.95) | 0.026 |
| Ser889Ser | C/T | 175 | 50.3 | 82 | 41.6 | Codominant 2 | 0.68 (0.37–1.22) | 0.19 |
| T/T | 43 | 12.4 | 21 | 10.7 | Dominant | 0.66 (0.46–0.94) | 0.021 | |
| Recessive | 0.84 (0.48–1.48) | 0.55 | ||||||
| Log-additive | 0.76 (0.58–1.00) | 0.045 | ||||||
| rs1936429 | A/A | 113 | 33.2 | 81 | 41.1 | Codominant 1 | 0.73 (0.49–1.07) | 0.11 |
| intron | A/G | 168 | 49.4 | 92 | 46.7 | Codominant 2 | 0.57 (0.32–0.99) | 0.047 |
| G/G | 59 | 17.4 | 24 | 12.2 | Dominant | 0.69 (0.47–0.99) | 0.045 | |
| Recessive | 0.68 (0.41–1.14) | 0.14 | ||||||
| Log-additive | 0.75 (0.57–0.97) | 0.028 | ||||||
| rs671228 | C/C | 225 | 64.1 | 135 | 67.2 | Codominant 1 | 0.83 (0.56–1.22) | 0.35 |
| intron | C/T | 115 | 32.8 | 58 | 28.9 | Codominant 2 | 1.17 (0.45–3.00) | 0.75 |
| T/T | 11 | 3.1 | 8 | 4.0 | Dominant | 0.86 (0.59–1.25) | 0.43 | |
| Recessive | 1.24 (0.48–3.16) | 0.66 | ||||||
| Log-additive | 0.92 (0.67–1.26) | 0.59 | ||||||
| rs16935163 | C/C | 309 | 88.5 | 163 | 82.3 | Codominant 1 | 1.58 (0.95–2.62) | 0.08 |
| intron | A/C | 40 | 11.5 | 33 | 16.7 | Codominant 2 | NA (0.00-NA) | NA |
| A/A | 0 | 0.0 | 2 | 1.0 | Dominant | 1.68 (1.02–2.76) | 0.044 | |
| Recessive | NA (0.00-NA) | 0.040 | ||||||
| Log-additive | 1.74 (1.08–2.81) | 0.024 | ||||||
P-values were calculated from logistic regression analyses. Bold numbers indicated significant associations. SNP, singe nucleotide polymorphism; OR, odds ratio; CI, confidence interval; n, number of subjects; NA, not applicable.