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. 2012 Apr 1;21(14):2689–2702. doi: 10.1089/scd.2011.0643

FIG. 1.

FIG. 1.

MO- and MOSN-mesenchymal stromal cells (MSCs) subjected to in vitro differentiation protocols. Both cell types display osteogenic, chondrogenic, and adipogenic differentiation in accordance to the minimal criteria proposed by the International Society for Cellular Therapy (ISCT) to define cultured human MSCs. MO-MSCs cultures at passages 5–6 exhibited a statistically significant enhanced potential to differentiate into the osteogenic and adipogenic lineages, reflected in a higher number of mineralization cumuli/field during osteogenic differentiation (A) and higher amount of Oil red (+) areas during adipogenic differentiation (B) (Mann-Whitney test; *P<0.05). (C) and (D) show representative pictures of osteogenic differentiation for MO-MSCs and MOSN-MSCs, respectively. (E) and (F) show representative pictures of adipogenic differentiation for MO-MSCs and MOSN-MSCs, respectively. MO-MSCs displayed more homogeneous areas of differentiation toward chondrogenic lineage (G) as compared to MOSN-MSCs (H).