FIG. 11.

A375N-established melanomas are resistant to the oncolytic activity of adenovirus Ad 5/3-κBF512HRE-E1A. Five doses of 1×10¹⁰ particles of the oncolytic adenovirus (vp) applied as intratumoral injections cannot control tumor growth. Ad 5/3-κBF512HE -E1A conditionally replicates in the tumor environment (secreted protein acidic and rich in cystein [SPARC] promoter in addition to hipoxia inducible factor [HIF] and NF-κB responsive motives). As a control, mice were injected with saline (PBS).