FIG. 6.

(A) Transendothelial migratory pattern of MO- and MOSN-MSCs toward cell-conditioned media and tissue-conditioned media. Cells were subjected to transendothelial migration assays toward conditioned medium from fresh tumor explants (Tumor), tissue adjacent to the tumor (AT), normal tissue (Normal), as well as A375N (melanoma cell line) and 578T (breast tumor cell line) conditioned medium; FBS indicates fetal bovine serum; DMEM (basal medium) shows chemokinetic activity. MO-MSCs present a more pronounced transendothelial migration response than MOSN-MSCs (*P<0.05, ***P<0.0001). Panels show representative fields of migrating MO- (B) and MOSN- (C) MSCs.