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. 2012 Apr 1;21(14):2689–2702. doi: 10.1089/scd.2011.0643

FIG. 7.

FIG. 7.

DiR+MO- and MOSN-MSCs were injected adjacent to a pre-established s.c. tumor. (A, B) show DiR+MO- and MOSN-MSCs (respectively) migrating from the adjacent site into the tumor site. (C) MO-MSCs show higher migration to the tumor site (s.c. breast tumor cells MDA-MB-231 or 578T, or melanoma xenograft A375N) than MOSN-MSCs (*P<0.05) as measured by fluorescence intensity as photon emission (p/sec/cm2/sr) (LiveImage3 software; IVIS Lumina Bioluminometer). MDA indicates MDA-MB-231. (D) shows a representative image of an unsectioned tumor excised from a sacrificed animal showing infrared signal corresponding to DiR+ MSCs. Migration occurs from the peripheral area of injection (denoted by C) into the tumor area (indicated by T).