TABLE 1.

Contrast of Change in Hamilton Depression Rating Scale Items Between the Selective NR2B Antagonist MK-0657 and the Broad NMDA Antagonist Ketamine^*

Item	HAM-D Symptom	MK-0657	Ketamine
		d	d
10	Psychic Anxiety	1.19	0.84
7	Work and Interests	0.80	1.29
5	Insomnia, Middle	0.71	0.27
4	Insomnia, Early	0.71	0.60
2	Guilt	0.64	1.14
9	Agitation	0.47	0.24
11	Somatic Anxiety	0.38	0.37
3	Suicidal Ideation	0.25	0.68
15	Hypochondriasis	0.10	0.50
12	Somatic Symptoms, GI	0.05	0.05
14	Genital Symptoms	0.04	0.56
6	Insomnia, Late	−0.16	0.50
16	Weight Loss	−0.19	0.23
8	Retardation	−0.27	0.39
1	Depressed Mood	−0.30	1.20
13	Somatic Symptoms, General	−0.76	1.13
	d ≥ .8
	d ≥ .5 and < .8
	d ≤ − .5

Positive effects sizes indicate lower levels (improvement) NR2B and negative ones indicate higher levels (worsening) on NR2B.

^*From Zarate et al.⁷