Figure 7.

Only GlyRα2-mediated inhibition modulates poststimulus suppression in ON GCs. A, Representative PSTH responses of WT and single- and double KO ON GCs during RF center stimulation with a bright (100 cd/m²) spot. The shaded regions represent poststimulus suppression at the offset of the stimulus (background, 20 cd/m²). B, A scatter plot shows the distribution of the area of poststimulus suppression (spikes × sec) across genotype, which is significantly lower in Glra2^−/− (open circles; n = 57) compared to WT (closed circles; n = 284) but similar in Glra3^−/− ON GCs (gray triangles; n = 84). The area of poststimulus suppression did not differ between and Glra2/3^−/− (open diamonds; n = 41) and Glra2^−/− ON GCs, but was significantly lower compared to Glra3^−/− ON GCs. Scale bar, 20 spikes per second. *p < 0.05; ***p < 0.001.