TABLE 2.

Characteristics of enhancer-associated histone modifications

Modification	Description	Refs.
H3K4me1/2	Associated with active, intermediate, and poised enhancers	22–24, 30, 31, 33, 58
	Widely considered to be the chromatin signature of enhancer elements
	May be necessary for recruitment of pioneer factors (i.e. FOXA1)
H3K9me3	Associated with poised enhancers	33, 34
	Established by SETDB1
H3K27ac	Associated with active enhancers	30, 31, 33, 46–48
	Established by P300
H3K27me3	Associated with poised enhancers	31–33
	Established by Polycomb-group protein EZH2
H3K36me3	Associated with active enhancers	33, 36, 38
	pol II is also present at H3K36me3-marked enhancers, consistent with ncRNA transcription from these enhancers