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DNMT3A cooperativity
There is a non-linear relationship between enzyme activity and enzyme concentration at low DNA concentrations.
| [DNA]/enzyme | Hill coefficient | EC50 | R2 |
|---|---|---|---|
| 500 nm | |||
| DNMT3A | 2.02 ± 0.22 | 89.5 | 0.97 |
| DNMT3A/DNMT3L | 2.08 ± 0.18 | 80.6 | 0.98 |
| 2 μm | |||
| DNMT3A | 1.09 ± 0.17 | NA | 0.98 |
