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. 2012 Jul 20;287(37):31116–31125. doi: 10.1074/jbc.M112.373647

FIGURE 2.

FIGURE 2.

Simulation of the binding of EGF to EGF receptor homodimers or EGFR/ErbB2 heterodimers. A, distribution of EGF receptor species in cells expressing 50,000 EGF receptors at increasing concentrations of EGF. B, distribution of EGF receptor and ErbB2 species in cells expressing 25,000 EGF receptors plus 25,000 ErbB2 molecules. C, distribution of EGF receptor species in cells expressing 50,000 EGF receptors lacking negative cooperativity (K22 = K21 = 1.9e9) at increasing concentrations of EGF.