TABLE 2.
Effects of specific inhibitors on the basal vascular tone
Summary of the effects of specific inhibitors, CB1 receptor antagonists O2050 (n = 9, 1 μm), AM251 (n = 7, 1 μm), and SR141716 (SR, n = 5, 1 μm), diacylglycerol lipase inhibitor THL (n = 7, 1 μm), AT1R inhibitor candesartan (Cand, n = 4, 10 μm), and nitric-oxide synthase inhibitor LNA (n = 4, 10 μm) on the basal vascular tone of rat gracilis arterioles and effects of O2050 (n = 4, 1 μm) and THL, n = 7, 1 μm) on mouse saphenous arteries. Note that CB1 receptor antagonist (inverse agonist) AM251 and NO synthase inhibitor LNA cause a significant elevation of the basal vascular tone, whereas the other inhibitors do not change the tone of these vessels in the applied doses. Data are the mean ± S.E. values. Differences in diameter values with inhibitors from control were considered as significant if p < 0.05. NS, not significant.
| Prepared segments | O2050 | AM251 | SR | THL | Cand | LNA |
|---|---|---|---|---|---|---|
| Gracilis arterioles | ||||||
| Contraction % | 0.06 ± 2.3 | 4.82 ± 1.2 | 2.17 ± 2.1 | 7.36 ± 5.2 | 2.11 ± 1.4 | 11.0 ± 5.1 |
| n | 9 | 7 | 5 | 7 | 4 | 4 |
| Statistics | NS | p < 0.05 | NS | NS | NS | p < 0.05 |
| Saphenous arteries | ||||||
| Contraction % | −3.3 ± 1.3 | 4.71 ± 3.9 | ||||
| n | 4 | 7 | ||||
| Statistics | NS | NS | ||||