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[15N]C1C2 NMR titration with Ca2+/CaM. Overlay of 15N HSQC spectra of human C1C2 before (cyan) and after the addition of Ca2+/CaM (magenta) at a molar ratio of 1:1 ([[15N]C1C2]/[Ca2+/CaM]). Inset, chemical shift changes of indole resonances of Trp196, Trp322, and Trp396.
