Figure 5.

Probabilistic global haplotype reconstruction using a generative mixture model. Each of the three haplotypes colored as in Figure 2 (A, blue; B, orange; and C, green) is represented as a chain of probability tables over the four nucleotides, where darker shading of a base indicates higher probability. The probabilities of traversing from the begin node to one of the haplotypes serve as an estimate for the haplotype frequencies. Each read is regarded as an independent observation from this statistical model.