Table VI.
Characteristics of five patients who developed grade III or IV hepatic dysfunction.
| Patient no. | |||||
|---|---|---|---|---|---|
|
|
|||||
| Characteristics | 1 | 2 | 3 | 4 | 5 |
| Gender | M | M | M | M | M |
| Age (years) | 43 | 41 | 43 | 35 | 71 |
| AJCC stage | IIIb | II | IIIb | II | IIIb |
| Radiotherapy | Yes | Yes | Yes | Yes | Yes |
| Chemo. regimens | mFOLFOX6 | EOF | mFOLFOX7 | mFOLFOX7 | mFOLFOX7 |
| Chemo. cycles | 7 | 4 | 5 | 7 | 5 |
| Isocenter dose (Gy) | 50.4 | 50.4 | 50.4 | 50.4 | 50.4 |
| Liver volume (ml) | 1297 | 875 | 1410 | 1177 | 1420 |
| Mean liver dose (cGy) | 2137 | 2313 | 2181 | 2164 | 2191 |
| V30 (%) | 26 | 22 | 24 | 25 | 27 |
| ALT (IU/l) | 538 | 245 | 326 | 341 | 240 |
| AST (IU/l) | 315 | 265 | 294 | 209 | 210 |
| Tbil (μmol/l) | N | N | N | N | N |
| Dbil (μmol/l) | 9.1 | N | 9.6 | N | N |
| HBV DNA reactivation | Yes | Yes | Yes | Yes | Yes |
| Lamivudine treatment | Yes | Yes | Yes | Yes | Yes |
| Outcome of dysfunction | R | R | R | R | R |
M, male; AJCC, American Joint Committee on Cancer; Chemo., chemotherapy; Gy, grays; V30, the volume fraction of the normal liver that received a radiation dose <30 Gy; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Tbil, total bilirubin; N, normal; Dbil, direct bilirubin; R, recovery.