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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Curr Opin Struct Biol. 2012 May 24;22(3):316–325. doi: 10.1016/j.sbi.2012.05.001

Figure 2.

Figure 2

Distribution of the statistical clustering z-score of ET residues in 10417 proteins from the PDB90. This z-score is the difference between the observed and the expected random clustering pattern in units of standard deviation. A z-score can be obtained at any ET coverage of a protein. This histogram shows the maximum clustering z-score between 0% to 50% coverage, which is representative of z-scores over most of this interval. The high values (94% with z-score > 2) show that evolutionarily important residues cluster together in the protein, as a general rule.