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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Curr Opin Struct Biol. 2012 May 24;22(3):316–325. doi: 10.1016/j.sbi.2012.05.001

Table 2.

Recurrent observations regarding ET residues suggest general rules of proteome evolution which link sequence, structure and function

PROTEOMIC RULES

  1. Amino acids may be ranked by evolutionary importance

  2. Top-ranked residues cluster in the protein structure

  3. Clusters predict functional sites

  4. Clustering quality correlates with prediction quality

  5. Maximizing clusters improves the quality of predictions