Table III.
Analysis of the distribution of XRCC1 and XPD triple-location genotypes in hepatocellular carcinoma (HCC) and control groups stratified according to alcohol consumption.
| Genotype | Alcohol consumption (+)
|
Alcohol consumption (-)
|
||||||
|---|---|---|---|---|---|---|---|---|
| HCC group (n) | Control group (n) | OR (95% CI) | P-values | HCC group (n) | Control group (n) | OR (95% CI) | P-values | |
| XRCC1 Arg194Trp | ||||||||
| CC | 85 | 94 | 1.00 | 0.22 | 34 | 34 | 1.00 | 0.70 |
| CT + TT | 112 | 96 | 1.29 (0.91–1.82) | 21 | 26 | 0.81 (0.58–1.64) | ||
| XRCC1 Arg280His | ||||||||
| GG | 143 | 152 | 1.00 | 0.10 | 50 | 54 | 1.00 | 1.00 |
| GA + AA | 54 | 38 | 1.51 (0.99–2.30) | 5 | 6 | 0.79 (0.28–2.18) | ||
| XPD Asp312Asn | ||||||||
| GG | 144 | 156 | 1.00 | 0.04 | 48 | 51 | 1.00 | 0.79 |
| GA + AA | 53 | 34 | 1.67 (1.10–2.60) | 7 | 9 | 0.86 (0.35–2.12) | ||
OR values were adjusted by gender, age, tobacco smoking, HBV antigen and family history.