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. 2012 Jun 19;8(5):267–274. doi: 10.1200/JOP.2011.000502

Table 1.

Model Inputs

Variable Base Patient Case Low High Source
Overall survival, months
    Carboplatin plus paclitaxel (EGFR negative or unknown) 8.1 7 9.5 Schiller et al21
    Carboplatin plus pemetrexed (EGFR negative or unknown) 12.0 7.6 17.1 Zinner et al,22 Scagliotti et al23
    Carboplatin, pemetrexed, and bevacizumab (EGFR negative or unknown) 14.1 10.6 19.6 Patel et al20
    Erlotinib (EGFR positive) 24.0 17.5 27.0 Rosell et al,9 Sequist et al10
Progression-free survival, months
    Carboplatin plus paclitaxel (EGFR negative or unknown) 3.1 2.8 3.9 Schiller et al21
    Carboplatin plus pemetrexed (EGFR negative or unknown) 5.5 3.4 8.3 Zinner et al,22 Scagliotti et al23
    Carboplatin, pemetrexed, and bevacizumab (EGFR negative or unknown) 7.8 5.2 11.5 Patel et al20
    Erlotinib (EGFR positive) 12.0 6.2 16.7 Rosell et al,9 Sequist et al10
Health state utilities
    Stable disease while receiving oral therapy 0.670 0.335 0.080 Carlson et al16
    Stable disease while receiving IV chemotherapy 0.653 0.327 0.670 Carlson et al,16 Nafees et al24
    Progressive disease 0.473 0.237 0.670 Carlson et al,16 Nafees et al24
    Stable disease plus
        Rash 0.640 0.320 0.670 Carlson et al,16 Nafees et al24
        Neutropenia 0.670 0.335 0.670 Expert opinion
        Febrile neutropenia 0.563 0.282 0.670 Carlson et al,16 Nafees et al24
        Pneumothorax 0.630 0.315 0.670 Expert opinion
        Hemorrhage 0.630 0.315 0.670 Expert opinion
        Nausea/vomiting 0.605 0.303 0.670 Nafees et al24
        Neuropathy 0.620 0.310 0.670 Carlson et al16
        Thrombocytopenia 0.650 0.325 0.670 Expert opinion
        Thrombosis 0.563 0.281 0.670 Expert opinion
Probabilities
    EGFR positive 0.15 NA NA Rosell et al,9 Shigematsu et al,18 Johnson et al25
    Not enough tissue for EGFR testing 0.50 0.30 0.70 Mok et al,7 Tsao et al26
    Noninformative rebiopsy 0.15 0.10 0.25 Expert opinion
    Pneumothorax (bronchoscopic biopsy) 0.01 0.01 0.05 Eberhardt et al,27 Facciolongo et al,28 Geraghty et al,29 Hergott et al30
    Pneumothorax (transthoracic needle aspiration biopsy) 0.09 0.05 0.15 Geraghty et al,29 Hergott et al30
    Hemorrhage resulting from biopsy 0.01 NA NA Facciolongo et al28
    Carboplatin plus pemetrexed AE
        Neutropenia 0.197 0.080 0.310 Zinner et al,22 Scagliotti et al23
        Febrile neutropenia 0.014 0.000 0.050 Zinner et al,22 Scagliotti et al23
        Thrombocytopenia 0.085 0.000 0.160 Zinner et al,22 Scagliotti et al23
    Erlotinib AE
        Rash 0.060 0.038 0.082 Genentech31
    Carboplatin plus paclitaxel AE
        Neutropenia 0.630 0.574 0.633 Schiller et al21
        Febrile neutropenia 0.040 0.017 0.063 Schiller et al21
        Nausea/vomiting 0.080 0.049 0.111 Schiller et al21
        Neuropathy 0.100 0.065 0.135 Schiller et al21
        Anemia 0.100 0.065 0.135 Schiller et al21
    Carboplatin, pemetrexed, and bevacizumab AE
        Anemia 0.091 0.027 0.155 Patel et al,20 Malhotra et al32
        Thrombocytopenia 0.039 0.000 0.082 Patel et al,20 Malhotra et al32
        Thrombosis 0.052 0.002 0.102 Patel et al,20 Malhotra et al32
        Febrile neutropenia 0.091 0.027 0.155 Patel et al,20 Malhotra et al32
Cost
    Erlotinib (150 mg per day for 30 days) $4,336 $2,168 $6,505 Drugstore.com33
    Pemetrexed (per cycle) $4,709 $2,354 $7,063 Centers for Medicare & Medicaid Services34
    Carboplatin (per cycle) $83 $41 $124 Centers for Medicare & Medicaid Services34
    Paclitaxel (per cycle) $86 $43 $129 Drugstore.com33
    Bevacizumab (per cycle) $6,538 $3,269 $9,807 Drugstore.com33
    Cleocin-T gel $105 $52 $157 Drugstore.com33
    Neupogen $3,866 $1,933 $5,799 Drugstore.com33
    EGFR gene copy test (CPT-88368) $243 $122 $365 Centers for Medicare & Medicaid Services35
    IV chemotherapy infusion per cycle (CPT-96413) $335 $168 $503 Centers for Medicare & Medicaid Services35
    Transthoracic needle biopsy (CPT-32405) $733 $366 $1,099 Centers for Medicare & Medicaid Services35
    Broncoscopic rebiopsy (CPT-31625) $840 $420 $1,261 Centers for Medicare & Medicaid Services35
    Other biopsy (CPT-47000) $732 $366 $1,098 Centers for Medicare & Medicaid Services35
    Chest tube (CPT-32551) $527 $286 $791 Centers for Medicare & Medicaid Services35
    Outpatient visit (CPT-99233) $96 $48 $143 Centers for Medicare & Medicaid Services35
    Inpatient visit (CPT-99255) $202 $101 $303 Centers for Medicare & Medicaid Services35
    Febrile neutropenia (MS-DRG 814) $7,057 $3,528 $10,585 Centers for Medicare & Medicaid Services36
    RBC transfusion per unit (CPT-36430) $515 $258 $773 Centers for Medicare & Medicaid Services35
    Pyridoxine (per month) $16 $8 $23 Drugstore.com33
    Oral ondansetron (treating one episode of vomiting) $12 $6 $18 Drugstore.com33
    IV ondansetron (treating one episode of vomiting) $100 $50 $150 Drugstore.com33
    Administering IV fluids $172 $86 $258 Centers for Medicare & Medicaid Services35
    Gabapentin $586 $243 $729 Drugstore.com33
    US/dopplers (for diagnosis of DVT CPT-93970) $254 $127 $381 Centers for Medicare & Medicaid Services35
    Enoxaparin (per day) $100 $50 $150 Drugstore.com33
    Rebiopsy pathology (CPT-88305 and -88342) $271 $136 $407 Centers for Medicare & Medicaid Services35
    Disease progression per month $5,219 $2,610 $7,829 Yabroff et al,37 Bureau of Labor and Statistics38

Abbreviations: AE, adverse event; CPT, current procedural terminology; DVT, deep vein thrombosis; EGFR, epidermal growth factor receptor; IV, intravenous; MS-DRG, Medicare severity–diagnosis-related group; NA, not applicable.